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Cancer Risk A review and discussion stated: ROS production is significantly increased in cancer cells because of mitochondrial dysfunction, altered metabolism, and frequent genetic mutations, resulting in an accumulation of large amounts of oxidized protein, DNA, and lipids as an adaptive response, cancer cells harbor elevated levels of ROS-scavenging molecules

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Therefore, various explorations for indirectly targeting KRAS have been performed over the past 40 years, of which most strategies are nonspecific and inefficient, including reducing the expression of KRAS, interrupting the membrane location of KRAS, interfering with the interaction between the KRAS and its effectors, inhibiting upstream and downstream signalling, and synthetic lethality approaches such as cyclin-dependent kinase inhibitors