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In terms of predicting drug resistance, bioinformatics also demonstrates enormous application potential

This fraction of cells first enters a drug-tolerant persistent state (drug tolerant state) under drug stress, and in this state, they gradually acquire stable drug resistance through adaptive mutations (7, 8), which can therefore become drug tolerant cells (DTCs)

The authors thank Lillian Cross, Kavon Kaboli, Elizabeth Baez for technical assistance for IL-13 delivery and Flexivent analyses of methacholine-stimulated airway hyperreactivity

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10.1007/s11655-018-3054-7 281 YangY.XuY.QianS.TangT.WangK.FengJ.et al (2023)