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This study reveals that, for optimal expansion, activated CD4 + and CD8 + T cells depend on serine, which is incorporated into the one-carbon metabolism cycle for purine metabolism

Progress in clinical trials related to p53 and relevance to RA While there are presently no clinical studies specifically addressing p53 pathways in RA, notable advancements have been achieved in the formulation of p53-targeted treatments in oncology that could potentially be repurposed or modified for chronic inflammatory disorders like RA

The treatment restored the estrous cycle, improved ovarian index and serum hormone levels, and increased numbers of sinus follicles and CL in the mice

that the thiol be sufficiently bulky to prevent S -alkylation, and that it should be less volatile than t BuSH

The exploration of novel biomarkers through metabolomics and proteomics, the construction of AI-based prediction models integrating multimodal data, and the design of biomarker-guided precision intervention clinical trials will be the focus of future research

Multifaceted activity of N-acetyl-l-cysteine in chronic obstructive pulmonary disease