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Ethical approval Compliance with ethical standards of research involving animals, animal experiments were approved by the ethical committee of Tehran University of Medical Sciences and were performed according to the universitys guidelines

"Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms"

Oxid Med Cell Longev 2022:4776243 Yang Y et al (2021) Dimethyl fumarate prevents ferroptosis to attenuate acute kidney injury by acting on NRF2

By promoting the cell-mediated immune response and up-regulating IL-2 and interferon-gamma (IFN-), while down-regulating IL-1, IL-6, TNF- and granulocytemacrophage colony-stimulating factor (GM-CSF), sulforaphane suppresses the metastasis [39]

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Intranasal administration is particularly studied for its ability to bypass the blood-brain barrier via retrograde axonal transport