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Discussion To identify emerging senolytics, we screened a library of electrophilic compounds, which can target proteins through covalent bond formation

All the other solvents and reagents were used as received without further purification

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POPs are mainly excreted through conjugation with GSH and this mechanism is extremely important for the health status, since exposure to POPs has been associated to diabetes, cardiovascular diseases and many other chronic diseases ( ROS production can occur at several intracellular sites but, for most cells, takes place in the mitochondria and the mitochondrial electron transport chain is the main cellular process of ROS generation in physiological circumstances ( 2 O 2 )

Toxicol Mech Methods (2003) 13(2):837