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Risk increases significantly in individuals with copper metabolism disorders (Wilsons Disease)

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together with the known requirement of monocytes to initiate disease in EAE 171 , this suggests an important interaction between monocytes and myelin processes in inducing demyelination

The most consistently recommended practical step, across the community discussion of this topic, is starting at a reduced frequency rather than daily use from the outset: two to three applications a week for the first couple of weeks, building up to daily use gradually rather than all at once

Accordingly , these activities do not include clinical, cosmetic, therapeutic, or diagnostic use