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THC increases oxidative stress, which is a well-established causal factor for increased neuropsychiatric risk, including schizophrenia

Diet, inflammation and prostate cancer The causes of cancer have been largely attributed to genetic and environmental factors, including lifestyle, and are generally thought of as either avoidable or unavoidable

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While the precise mechanisms remain incompletely understood, these neurons exhibit particular vulnerability to oxidative stress due to their high basal metabolic activity, autonomous pacemaking requiring intense calcium cycling, and ROS generation during dopamine metabolism [187]