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Veterinarians may wish to default to chewable or palatable formulations when they are available or consider alternatives to oral medications when longer-lasting injectables are indicated and available to reduce pet owner anxiety and stress

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The transmembrane protease-activated receptor 2 (PAR-2), which is expressed on keratinocytes and has an important role in the formation of melanocyte dendrites and the phagocytosis of melanosomes by keratinocytes [129, 130], could also be specifically blocked by compounds to decrease epidermal pigmentation [131]

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