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It is also possible that at very low O 2 (inlet air at 0% O 2 ), the small flux to S assimilation is explained not only by low photorespiration but also the downregulation of the aspartate pathway of amino acid synthesis (and thus methionine production) under hypoxic conditions 34,35

Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier

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The horizontal axis represents the directional intensity of the metabolite peak abundance fold change (FC) and the vertical axis represents statistical significance