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When a freeze-dried peptide meets a solvent, each molecule has to interact with water for the solid to dissolve

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The following pharmacokinetic parameters were calculated for both analytes after BUP-XR administration at each injection location: AUC 028 days (area under the plasma concentrationtime curve [AUC] from time zero [Day 1] to 28 days post-dose [Day 29]), AUC last (AUC until the last quantifiable plasma concentration), C max (maximum observed plasma concentration), T max (time to maximum observed plasma concentration), and C trough (concentration on Day 29)

Limited clinical data exists, but anecdotal reports suggest constipation rates around 1015% at doses above 600mg daily

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National Research Council (2000)