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Interactions between extracellular matrix and growth factors in wound healing

doi:10.1038/sj.cdd.4401837

The cosmetic endpoint you're chasing requires sustained dermal exposure over weeks, not peak plasma concentration in the first 90 minutes

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As crucial regulators of local immune responses and tissue repair, macrophages in diabetic wounds show dysregulated switching from M1 to M2, resulting in a poor regenerative environment, exacerbated tissue damage, and delayed wound healing 63