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Similarly, recent clinical study has explained that the progress of pathologic conditions may be linked with sudden fall of GSH levels and reflecting the elevated production of ROS

Exposure to OTA can down-regulate the formation of GCLC, the rate-limiting enzyme in GSH synthesis, which will result in a reduction in the intracellular level of GSH [73]

[DOI] [PMC free article] [PubMed] [Google Scholar] Butterfield, D

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(2009) Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells