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These are the active forms of Vitamin B12

The symptoms can be divided into two stages, early stage and late stage

Within this framework, the response to the master pro-fibrotic cytokine TGF- is thought to be dysregulated in SSc

Its also needed for DNA repair, the formation of new red blood cells, and converting homocysteine to methionine

These signs include fatigue, weakness, constipation, reduced appetite, weight loss, along with numbness and tingling sensations in the extremities

Sodium loading will tend to produce volume expansion, whereas sodium loss (e.g., due to vomiting, diarrhea, or drug management with diuretics) will lead to volume depletion