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Hematoxylin and eosin (HE) staining revealed that DON treatment impaired ovarian health, leading to follicular atresia and nuclear pyknosis, which were alleviated by melatonin supplementation (Supplementary Fig

As type I interferons, known to be upregulated in SLE, transduce their signal through JAK, the JAK1 inhibitor GSK2586184 was used in a small trial to block the expression of interferon-related genes in SLE

According to Suzuki et al., through restricting cell metabolism, the cancer suppressor menin stops activated CD8 + T lymphocytes from developing functional abnormalities [63] (Fig