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CVD was defined as having a medical history of coronary artery disease (CAD), heart failure, or stroke

The pertinent findings of this study are: 1) enhanced hepatic de novo serine synthesis is required for SAAR to improve glucose tolerance, 2) concurrent with transcriptional activation, a serine synthesis-GSH-lysine lactoylation feedback loop may underlie the increased hepatic serine synthesis in response to SAAR, and 3) hepatic serine synthesis is not necessary for the SAAR-mediated decline in adiposity and liver triglycerides

Ryu J, Ku BM, Lee YK, Jeong JY, Kang S, Choi J, et al

Do not scrub hard or over-treat, as that will cause irritation or aggravate pigmentation

While basic cognitive abilities return within months, complete recovery of complex functions like multitasking and abstract thinking may take years

In contrast, there is a marked reduction in CG methylation in neuronal cells and oligodendrocytes in the prefrontal cortex, especially in cis-regulatory regions, leading to the upregulation of downstream genes (Mendizabal et al., 2019)