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It has been demonstrated that folic acid-targeted nanoparticles (FA-DCNP) loaded with glutamine inhibitor DON and calcium carbonate CaCO3 can target M2-TAMs and attenuate M2-TAMs activity

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These findings align with prior evidence indicating Mgs ability to attenuate stress responses via suppression of the hypothalamicpituitaryadrenal (HPA) axis [27, 29, 31, 32]

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Any factor that affects this intraocular environment, such as aging, genetics, metabolic abnormalities, trauma, radiation, poisoning, local nutritional disorders, and certain systemic metabolic or immune diseases, can directly or indirectly cause the lens to become opaque