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In neurological diseases, in response to pathological changes in the nervous system, microglia undergo morphological changes, and these cells secrete a different group of inflammatory mediators, including chemicals, cytokines, and cytotoxic molecules

These signals collectively sustain capillary networks, preserve BBB stability, and promote vascular homeostasis

Determining the optimal duration of pharmacological interventions, potential long-term side effects, and the impact of HU management on cardiovascular outcomes requires further investigation

10.1016/j.rvsc.2022.02.015 35 Centers for Disease Control and Prevention (CDC) (2015b)