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High (variant is assumed to have disruptive impact in the protein: stop codon gained and loss of function), low (harmless or unlikely to change protein behavior: synonymous codon), moderate (non-disruptive variant that might alter protein effectiveness: missense codon and inframe codon loss) and modifier (non-coding variants or variants affecting non-coding genes: exon variant and downstream gene variant) are parameters used by SnpEff to correlate SNPs and their putative impact on protein functioning

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However, Th1 cell-induced IFN and TNFa overproduction in response to SARS-CoV-2 infection, as well as the massive death of virus-infected cells, can result in damaged lung tissue and trigger acute respiratory distress syndrome