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Certain agents, notably ethambutol and linezolid, carry ocular toxicity risks such as optic neuropathy, while multidrug-resistant TB further limits effective options (Libershteyn, 2016)

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We are finalizing with minor wording modifications to revise 425.512(a)(7)(ii) and add new paragraphs (a)(7)(ii)(A) and (B) to indicate for performance year 2025 and subsequent performance years, an ACO will receive the higher of the ACO's health equity adjusted quality performance score or the equivalent of the 40th percentile MIPS Quality performance category score when an ACO reports all of the required measures in the APP Plus quality measure set, meeting the data completeness requirement for each measure in the APP Plus quality measure set, and receiving a MIPS Quality performance category score, and the ACO meets either of the following: ++ The ACO's total available measure achievement points used to calculate the ACO's MIPS Quality performance category score is reduced under 414.1380(b)(1)(vii)(A)

Over the past decade, peptide-based drugs have become one of the most commercially successful classes of medicines in modern pharmacology

doi:10.1016/S0003-4975(03)01352-3

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