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Thus, while each platform has demonstrated proof-of-concept efficacy, the choice of design must balance responsiveness, stability, and biosafety to ensure clinical applicability

On the other hand, melatonin has an apoptotic cytotoxic effect on myeloid cell lines HL-60, B lymphoma, MCF-7, prostate cancer cells LNCaP, or hepatocarcinoma HepG2 [43]

Regulation of the NF-B-mediated transcription of inflammatory genes

Depositions of extracellular amyloid plaques and intracellular neurofibrillary tangles in the hippocampus and cortex are striking features of Alzheimers disease