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In addition, Complex I can be easily S-glutathionylation by an increase in GSSG (Beer et al., 2010

We additionally hypothesized that held-out metabolites that the model failed to ever generate would tend to occupy more distinct regions of chemical space with few similar structures in the training set

Some medicines and hydroxocobalamin may interfere with each other

(they will need to do their own TSH test to confirm this) What they SHOULD have done already is organise their own TSH test between (6 weeks -3 months) after the dose reduction to check her TSH on the lower dose for themselves