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Although the therapeutic advantages of EVs are evident, there are still shortcomings in practical application, such as low therapeutic efficiency and rapid degradation rates (Sterzenbach et al., 2017

The deletion of focal adhesion kinase (FAK) in CAFs leads to increased activation of cytokine signaling pathways and the upregulation of the expression of C-C chemokine ligand (CCL)6, CCL11, CCL12 and pentraxin-3, which increase the activity of glycolysis processes in breast and pancreatic cancer cells [331]