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While enhancing the activation of sirtuins has emerged to increase lifespan and healthspan, aberrant activation of PARPs and NAD+ glycohydrolases, such as CD38, may exert the opposite effect exacerbate aging

Alternatively, pro-oxidant agents or metabolic inhibitors can further elevate ROS levels, tipping the redox balance toward cell death [32]

Supporting Cellular Health Glutathione is essential for cellular processes, including DNA synthesis and repair

Another widespread pollutant is N,N-diethyl-3-methylbenzamide (DEET), the most widely used insect repellent in the world

KPV exerts its anti-inflammatory function inside cells, where it inactivates inflammatory pathways by a decrease in pro-inflammatory cytokine expression

American Type Culture Collection, Rockville, Maryland, USA) were cultured in Dulbeccos modified Eagles medium (DMEM