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RPMI-8402 and NCI-H125 labelling was performed 48 h after NKX21 knockdown in serineglycineglucose-free RPMI-1640 (Teknova) supplemented with 13 C 6 -glucose (Sigma-Aldrich) to a final concentration of 2 mg/mL and with 10% dialyzed serum (Life Technologies, A3382001) for 48 h

Although normally only active in the presence of low oxygen levels, exposure to the oxygen species H 2 O 2 and HOCl also leads to its activation in several Salmonella enterica species, Haemophilus influenzae and other pathogens [276]

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Persistent Nrf2 signaling has been associated with enhanced proliferation, metastatic dissemination, and resistance to multiple chemotherapeutic agents