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Role of microRNA-155 in triptolide-induced hepatotoxicity via the Nrf2-dependent pathway

410 BAT with multilocular lipid droplets is rich in mitochondria and significantly expresses uncoupling protein 1 (UCP1), PGC-1, and PRDM16

Given a previous study showing that GPX4 had decreased activity in NEC, it appears that the elevation of GPX2 in NEC could be a response to oxidative stress

doi: 10.1016/j.ijrobp.2017.05.035 96 ChaoMHoHChanYTanAPhamTBoltonDet al

Materials and methods The study was conducted in vitro on human LCA cells (A-549) and the study protocol application groups in vivo on Swiss albino mice treated with benzo[a]pyrene only and were not received any treatment for inducing LCA, and only after LCA induction the study treatment protocol began, treatment was daily with CCFHIONP as HIFUSPDT sensitizer with or without exposure to laser (IRL) or high-frequency ultrasound (HIFUUS) or a combination of laser and/or high-frequency ultrasound for 3 min for 2 weeks

In healthy tissue, the peptide maintains NO homeostasis by modestly increasing endothelial NOS (eNOS) for beneficial vasodilation while suppressing inducible NOS (iNOS) that drives pathological inflammation