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Epidemiological studies reveal a U -shaped association between iodine intake and cognition, where both deficiency and excess correlate with poorer outcomes

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Additionally, the absolute number of B cell precursors in the bone marrow declines with age, particularly during adolescence [353], though B lymphopoiesis continues throughout adulthood [354]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Keller SM, Papazoglou S, McKeever P, Baker A, Roth JA