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Revisiting the paraquat-induced sporadic Parkinsons disease-like model

Thermal sensitivity testing demonstrated that as a group, at baseline, the subjects exhibited a reduction of function of cold detection threshold of all three regions tested, and reduced function in warm detection threshold in the foot and hand (Figure 7)

Since AD is a multifactorial disease (see redox proteomics results that show many pathways affected because of secondary oxidative modification), the use of a single-molecule/single-target approach may result in limited efficacy

doi: 10.3389/fcvm.2025.1518549 238 JenningsAThompsonASTresserra-RimbauAONeillJKHillCBondonnoNPet al