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doi: 10.1038/ncomms12276 108 BurnhamELHalkarRBurksMMossM

Results The isolated pHAT domains of TaOGA and hOGA form homodimers Although hOGA is a multi-domain protein including a C-terminal pHAT domain, structural studies of the full-length enzyme have been hampered by the presence of several predicted large disordered regions (Fig

This can lead to pancreatitis and other metabolic issues if left unresolved

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For older adults on long-term PPIs, periodic B12 monitoring is appropriate and a daily sublingual methylcobalamin is a reasonable preventive measure to discuss with the prescriber

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