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10.3389/fimmu.2011.00035 [DOI] [PMC free article] [PubMed] [Google Scholar] 175

N-Acetyl Cysteine (NAC) : Supports glutathione production and has mucolytic properties that can help with respiratory symptoms

Firstly, it can cause direct damage to a plethora of cellular iron-containing targets (including the enzyme aconitase and mitochondrial electron-transport complexes carrying FeS clusters)

The most frequently observed adverse reactions were injection site pain in 7 patients (2.6 %), hypersensitivity (such as rash, fever, and itching) in 1 patient (0.4 %), injection site indurations in 1 patient (0.4 %), and gynaecomastia in 1 patient (0.4 %)

7.3.6 Clinical translation Successful translation of ferroptosis-targeted therapies requires methodical progression through several key stages: validation of candidate biomarkers in well-characterized human cohorts, optimization of inhalation formulations for consistent pulmonary deposition, and demonstration of safety and efficacy through rigorously designed clinical trials