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Polyneuropathy typically presents gradually, beginning with paresthesia known as burning feet, followed by gait disturbances and variable muscle weakness in the lower limbs ( In the CNS, thiamine deficiency can lead to Wernickes encephalopathy, characterized by nystagmus, ophthalmoplegia, mental status changes, and unsteady stance and gait, due to apoptotic cell death in sensitive brain areas, mainly areas with high metabolic requirement, causing symmetrically distributed lesions among structures such as the third and fourth ventricles, besides dorsomedial thalamus (42)

CPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cells

It improves the functioning of the immune system, has a nervous system protection effect, increases the bodys resistance to infections, can speed up the recovery from diseases, and increases the bodys energy levels and vitality (3)

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Moreover, -tocopherol exhibits a pronounced protective effects against arthritis [30], cancer [31], aging [32], cataract [33], haemolysis [34] and uraemia [35]