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Perfusion culture process plus H2O2 stimulation for efficient astaxanthin production by Xanthophyllomyces dendrorhous

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National Institute on Alcohol Abuse and Alcoholism,

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Mechanistic investigations in human somatic cell cultures have suggested that Epithalon may: Activate telomerase in vitro Support telomere maintenance and reduce the accumulation of DNA replicationassociated errors Potentially modulate the balance between cellular senescence and replicative capacity in experimental systems In parallel, Epithalon has been examined for its ability to interact with oxidative stress pathways and free radical markers, which may contribute to observed longevity-related effects in certain preclinical models

Its reduced form (GSH) donates electrons to neutralize peroxides through glutathione peroxidase (GPx) and is regenerated by glutathione reductase (GR) using NADPH