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Additionally, supplementation may be necessary, especially for dogs with specific health conditions or those that are more susceptible to oxidative stress

The onset of these diseases is often accompanied by abnormalities in mitochondrial energy metabolism, increased oxidative stress, and exacerbated inflammatory responses, further aggravating the pathological processes

308 Abnormal intracellular calcium signaling could also impact various organelles such as the ER, mitochondria, and lysosomes

R.RamamurthyS.VichitraC.SharmaA.et al (2024)

A notable exception to this biosynthetic capability are the nematode Caenorhabditis elegans and other parasitic helminths, which are heme auxotrophs 25