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Mice aged 1224 weeks and sex-matched were used for all experiments

Sulfonylureas: In vitro studies indicate that berberine coadministration may compromise the metabolism of sulfonylureas or mutually affect the metabolism of both compounds (32)

Beyond DFX, newer compounds such as deferasirox, dauricine, and N -acetylcysteine offer alternative approaches by enhancing glutathione peroxidase 4 activity and replenishing antioxidant defenses 27

A circadian clock gene, Rev-erb, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression

These results indicate that lobetyolin efficiently mitigates DHEA-induced glucose metabolic disturbances in mice, underscoring its potential significance in regulating metabolic syndrome

For practical reasons, rats and mice are the main species used today for investigating mechanisms of APAP toxicity and evaluating therapeutic interventions