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Notably, core fucosylated MSLN (Cf-MSLN) was found to be reduced in tumor tissues and serum compared to healthy controls, suggesting its potential as a more specific biomarker for pancreatic cancer than total MSLN levels

Adiponectin and GCs seem to antagonize each other, with adiponectin levels being reduced in Cushings patients and elevated in ADX mice, while corticosterone production is reduced by adiponectin administration 64

Med Sci Monit Int Med J Exp Clin Res 25:4068 Li Y-C, He S-M, He Z-X et al (2014) Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells

13 For COVID-19 repurposing of an existing clinically approved drug, it is pivotal to demonstrate its antiviral, anti-inflammatory, and related effects against SARS-CoV-2 in cell-based systems in vitro

Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations E-GPx: extracellular glutathione peroxidase C-GPx: cellular glutathione peroxidase GPx: selenium-dependent glutathione peroxidase ROS: reactive oxygen species t-BuOOH: tert-butyl hydroperoxide GAPD: glyceraldehyde-3-phosphate dehydrogenase FiO2: fraction of inspired oxygen References Quinlan T, Spivack S, Mossman BT 1994 Regulation of antioxidant enzymes in lung after oxidant injury