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Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic

Chemical synthesis (e.g

After overnight incubation at 4C, wells were washed thrice with PBS and blocked with 1% fatty acid free BSA (Sigma) in PBS for 1h at room temperature (RT)

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Metabolic analysis of LS organoids revealed lactic acidosis and glycolysis/gluconeogenesis elevated, which would confirm the alterations in mitochondrial reprogramming described during neurogenesis