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Further evidence that Treg cells require ETC function comes from the observation that Treg cellspecific genetic loss of mitochondrial complex III function incurs fatal autoimmunity and increases antitumor immunity

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The pathways of ROS production are diverse, involving numerous signaling cascades

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Ipser JC, Stein DJ, Hawkridge S, Hoppe L

Ozone therapy versus hyaluronic acid injections for pain relief in patients with knee osteoarthritis: preliminary findings on molecular and clinical outcomes from a randomized controlled trial