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have found negative correlation with RLS severity and 11C-diprenorphine uptake in the caudate nuclei, medial thalami and anterior cingulate gyri, although pathophysiological significance of this finding is not clear [16]

10.1038/s41574-021-00629-4 61 JohnsonJ.CanningJ.KanekoT.PruJ

PMID: 30252305

Nasfi, F

there are also views that AD is an autoimmune disease, and that A is regarded as a cytokine and immune peptide with both immunomodulatory and antimicrobial properties