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Although Nrf2 is a master regulator of cellular redox homeostasis following stress, Nrf2 activity in vascular and other cell types is known to decline [131] and could play an important role in age-related cellular dysfunction and disease onset

Glucose uptake assay Glucose uptake was monitored with the fluorescent deoxyglucose analogue 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) (Thermo Fisher Scientific, San Jose, CA, USA) 47

doi: 10.1038/s41418-021-00814-y

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