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Researchers studying carnitine function and requirements utilized supplementation to support energy and substrate metabolism in an animal model

Level of evidence (nicotinamide): 1aii Because many of the syndromes described above are rare, few clinical trials have been conducted in these specific populations

In addition, the bioenergetic health index (BHI) (21) was calculated using the following formula: BHI = log (SRC*ATP)/(NMRR*PL)

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J Hepatol 57:837843 Xu Z, Chen L, Leung L, Yen TS, Lee C, Chan JY (2005) Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

This work was supported by the National Science Centre in Poland (grant 2015/18/M/NZ3/00348 to I)