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SAM is regenerated again and again in a permanent cycle: it releases its methyl group in various reactions, and then goes through a series of reaction steps, through which it receives a new methyl group and is thus available again as a methyl donor

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Rudnik-Jansen I, Colen S, Berard J, et al

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Exploratory research on peptideprotein interactions in cell and tissue preparations

The result is that current research can only correlate changing hormones with symptoms for averaged populations of women, and with only a rough idea of timing of these events