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its Fe-S occupancy is rate-limiting for overall lipoylation and is gated by FDX1, a ferredoxin that donates electronsand, indirectly, Fe-S-derived ironto the lipoate synthase reaction

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Interestingly, degeneration of dopaminergic neurons after administration of MPTP was attenuated in NOX2-deficient mice as compared with wild-type controls, suggesting the contribution of NOX2 in this process

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