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Copper is an essential trace mineral involved in: Collagen synthesis Elastin formation Antioxidant defense Tissue remodeling Blood vessel formation Cellular repair mechanisms GHK-Cu acts as a carrier and signaling peptide that helps regulate tissue repair and cellular communication

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Concretely, the beneficial commensal genera decreased, including FP (226, 227), Clostridiaceae , Rikenella , Bacteroides , Prevotella , Roseburia , Pseudobutyrivibrio , Escherichia/Shigella , and Raecalibacterium (228), whereas the pathobiont genera rose, including Lactobacillus (229), Ruminococcus , Akkermansia , Bifidobacterium , Fusobacterium , Erwinia , and Streptococcus (230, 231)