Reasons for fatigue Fatigue stems from physical or mental factors, including things like: Metabolic conditions such as diabetes, kidney disease, Cushing syndrome, and thyroid conditions Mental health issues such as depression, stress, eating disorders, anxiety, and burnout Cardiovascular conditions affecting blood flow, such as arrhythmias, heart disease, and heart failure Medications such as antidepressants, antihistamines, steroids, statins, and sedatives Sleep problems due to insomnia, narcolepsy, jet lag, and sleep apnea Chemical imbalances due to too little or too much of various essential nutrients, vitamins, and minerals Facts about B12 deficiency Also referred to as cobalamin deficiency and named after the scientific term for this water-soluble nutrient, a B12 deficiency can result from low dietary intake or from your body not absorbing the vitamin properly

European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy
According to a review published in Nutrients , for healthy vegans and vegetarians to meet the daily requirement for vitamin B12, taking one oral dose of 50100 micrograms daily appears to be sufficient
Personalizing Your Vitamin Intake Since both B12 and D are available through dietary sources, you can benefit from personalizing your nutrient plans
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Monitoring, Labs, and Outcome Tracking Baseline labs typically include serum B12, methylmalonic acid (MMA), and homocysteine