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Table 2 The studies of proteins and bioactive peptides and their effects and mechanisms on enhancing physical strength and endurance

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Dupont, J., Pierre, A., Froment, P

High-salt diet is an important factor for hypertension, which can deplete Lactobacillus in mice (108), while candesartan can counteract the decrease of Lactobacillus caused by hypertension, and candesartan treatment also increases the intestinal expression of genes encoding tight junction proteins (such as zonula occludens, occludin, and claudin-1), improving increased intestinal permeability caused by hypertension and preventing gut microbiota translocation (105)

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Additionally, in muscle tissue, mitochondrial translation and respiratory genes were also induced, and moreover, patients demonstrated a mild clinical improvement