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The detailed analysis of the differences in the sample size, in the number of RCTs included for each outcome, and in the results between the present study and the Cochrane meta-analysis is detailed in Table 3

Additionally, the intracellular GSH was not changed at 12 hours between control and CSE but by 24 and 48 hours there was significantly increased intracellular GSH in the CSE exposed cells (Figure 1B)

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SJS lesions contained lower concentrations of granulysin compared to TEN lesions, which could explain the differences of clinical severity in these pathologically identical conditions

NAC is the primary option for patients with liver injury requiring pharmacological treatment ( FIGURE 5 Because of the absolute role of mitochondrial oxidative stress and dysfunction in the pathogenesis of AILI, the FDA approved the antioxidant NAC in 2004 to treat intrinsic DILI caused by excessive APAP intake