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TLR4 activation may lead to ROS signaling via direct interaction between TLR4 and NADPH oxidase (Gill et al., 2010

456 In the spinal cord, the influx of neuropathic signals to the dorsal horn leads to central sensitization, characterized by increased spontaneous neuronal activity, lowered activation thresholds for peripheral stimuli, heightened responses to sub-threshold stimuli, and expansion of receptive fields

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doi:10.1212/WNL.84.14_supplement.P1.238

3,000 mg per serving