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While gastrointestinal side effects were common, they were mostly not acute

There were faster granulation tissue formation, re-epithelialization, dermal remodeling, and collagen deposition through extracellular signalregulated kinases (ERK)1/2 signaling pathway as well as its downstream targets, including c-Fos, c-Jun, and egr-1

The accelerated healing in burns of treated mice includes the activity of the pentadecapeptide BPC 157 (Figure 1), given locally (as a cream) or systemically (ip), on the inflammatory cells, edema, reticulin, collagen, necrosis, blood vessel formation, number of preserved follicles, re-epithelization, tensile breaking strength, and water content in burned skin

After a single IV administration, BPC157 was rapidly eliminated from the plasma of rats, and the average elimination half-life (t 1/2 ) was 15.2 min

Recognizing non-response allows pivoting to alternative approaches rather than continuing ineffective treatment