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Analogously, LNCaP cells were cultured in CDSS-containing medium for 8 weeks to generate castration-resistant LNCaP-CR cells, followed by Enza exposure (50 M, 2 weeks) to derive LNCaP-C/Enza-R cells which were then used, together with LNCaP-AD cells in ABT-199 sensitivity studies (supplementary Fig

Animal studies show minimal toxicity at therapeutic doses over 11 days, with no observed hepatotoxicity, nephrotoxicity, or CNS effects

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Recovery, Lifestyle Changes, and Long-Term Follow-Up Recovery involves 13 days in hospital, a staged dietary progression over six weeks, and lifelong nutritional supplementation

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This article summarizes what preclinical studies have explored, including proposed mechanisms such as vascular signaling and inflammatory modulation