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Glutathione is also an integral part of the bodys antioxidant defense system, so other parameters need to be considered in conjunction with glutathione levels: Glutathione is made up of three amino acids that are combined to create a peptide that behaves as a powerful antioxidant and also has several crucial roles in the body

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In pancreatic cell lines, hypoxia downregulated the expression of full-length WRS and upregulated T2-TrpRS (Paley et al., 2011)

In the CNS, mitochondria are key not only for sustaining neuronal energy demands but also for regulating neurotransmitter synthesis, calcium buffering, oxidative stress responses and apoptotic signaling (84) (Fig