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Canada J PediatrHematolOnco 37:595599 Walter O, Maquet J, Derumeaux H, Moulis G, Lafaurie M (2021) Validation of discharge diagnosis of sickle cell disease vaso-occlusive episodes in the french hospital electronic database

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SFB have a reduced genome size of ~1.51.7 Mb 32,34 and are metabolically unique symbionts that, based on their reduced number of predicted coding sequences (CDS) 35 and metabolic capabilities 34 , lie in between obligate and facultative bacterial symbionts, underscoring their intimate relationship with the host despite their limited penetrative capacities